Latikafusp抗體|Latikafusp(AMG 256)|PD-1抗體IL-21突變蛋白|佰樂(lè )博生物代理AntibodySystem

Latikafusp (AMG 256)是一種雙功能融合蛋白，包含靶向PD-1的抗體和IL-21突變蛋白，旨在向PD-1+細胞提供IL-21通路刺激。Latikafusp可以啟動(dòng)和延長(cháng)細胞毒性和記憶T細胞的活性，并誘導抗腫瘤免疫。Latikafusp具有用于實(shí)體瘤研究的潛力。Latikafusp可導致免疫原性介導的反應的產(chǎn)生。

鏈接：https://www.antibodysystem.com/product/8048.html

名稱(chēng)：Research Grade Latikafusp (AMG 256)抗體

別名：Bispecific antibody, AMG 256, AMG-256, AMG256

CAS: 2552814-07-8

貨號：DHJ59501

宿主：Homo sapiens

適用物種：Human

存儲緩沖區：0.01M PBS, pH 7.4.

形式：Liquid

純度：>95%

克?。?/span>Monoclonal

同型：IgG1-lambda2

應用：Research Grade Biosimilar

靶點(diǎn)：IL21R, NILR, Interleukin-21 receptor, IL-21R, IL-21 receptor, CD360, Novel interleukin receptor, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

生物活性：Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research.

內毒素水平：Please contact with the lab for this information.

UniProt：Q9HBE5 & Q15116

用途范圍：僅用于科研

儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

產(chǎn)品購買(mǎi)聯(lián)系方式：027-65279366 /18162686757

郵箱：biolab-reagents@atagenix.com

QQ：2663991332

參考文獻：

[1]. Greg Durm, et al. Abstract CT205: Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, PD-1 antibody x IL-21 mutein bifunctional fusion protein, in patients with advanced solid tumors. Clin Cancer Res. 2022 Apr 1;28(7):1294-1301.  [Content Brief]

[2]. Gregory Durm, et al. 417 Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, IL-21 receptor agonist and anti-PD-1 antibody, in patients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 2020, 8(Suppl 3).

[3]. Kroenke Met al. Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein. Front Immunol. 2024 Jan 26;15:1345473.  [Content Brief]