介紹：DNA-RNA雜交種是真核細胞中的自然現象，這些雜交體的水平在具有高轉錄活性的位點(diǎn)增加，例如在轉錄起始、抑制和延伸期間。由于RNA-DNA雜交體會(huì )影響基因組的不穩定性，因此S9.6抗體是一種有用的試劑，有助于研究這些雜交體在DNA復制或其他細胞過(guò)程中形成的R環(huán)和病變的后果。S9.6抗體可有效識別用于微陣列研究的RNA-DNA雜交。

佰樂(lè )博生物：佰樂(lè )博生物代理Antibodysystem，ProteoGenix品牌，是亞洲區運營(yíng)總代理商

鏈接：https://www.antibodysystem.com/product/7992.html

名稱(chēng)：Anti-DNA-RNA Hybrid Antibody(S9.6)單克隆抗體

別名：DNA-RNA Hybrid，clone S9.6，S9.6單克隆抗體

貨號：RGK60001

宿主：Mouse

適用物種：General

應用：CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF

形式：Liquid

純度：>95%

克?。?/span>Monoclonal

同型：IgG2a, kappa

內毒素水平：Please contact with the lab for this information.

表達系統：Mammalian cells

用途范圍：僅用于科研

儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

產(chǎn)品購買(mǎi)聯(lián)系方式：027-65279366 /18162686757

郵箱：biolab-reagents@atagenix.com

QQ：2663991332

參考文獻：

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids. PMID: 33830170

Detection of R-Loop Structures by Immunofluorescence Using the S9.6 Monoclonal Antibody. PMID: 35704182

High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing. PMID: 31053798

S9.6 Antibody-Enzyme Conjugates for the Detection of DNA-RNA Hybrids. PMID: 37194248

S9.6-based hybrid capture immunoassay for pathogen detection. PMID: 38110611

R-Loop Analysis by Dot-Blot. PMID: 33554969

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage. PMID: 29742442

Structural basis of R-loop recognition by the S9.6 monoclonal antibody. PMID: 35347133

Immunoprecipitation of DNA:RNA Hybrids Using the S9.6 Antibody. PMID: 32681514

Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging. PMID: 34232287

Mapping R-Loops and RNA:DNA Hybrids with S9.6-Based Immunoprecipitation Methods. PMID: 34515688

Cryo-EM structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids. PMID: 35550870

Modifications and interactions at the R-loop. PMID: 32961406

The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences. PMID: 28594954

R-Loop Detection in Bacteria. PMID: 35704183

Approaches for Mapping and Analysis of R-loops. PMID: 38666626

New insight into the biology of R-loops. PMID: 32516653

Quantitative DNA-RNA Immunoprecipitation Sequencing with Spike-Ins. PMID: 35704206

The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast. PMID: 29289567

Genome-wide map of R-loops reveals its interplay with transcription and genome integrity during germ cell meiosis. PMID: 36396044

The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6. PMID: 23784994

A rapid and simple method for simultaneous determination of three breast cancer related microRNAs based on magnetic nanoparticles modified with S9.6 antibody. PMID: 36682580

Detection of TERRA R-Loops at Human Telomeres. PMID: 35704191

DNA-RNA Hybrids at Telomeres in Budding Yeast. PMID: 35704190

Best practices for the visualization, mapping, and manipulation of R-loops. PMID: 33411340

Immunofluorescence microscopy of G-quadruplexes and R-loops. PMID: 38521582

Strengths and Weaknesses of the Current Strategies to Map and Characterize R-Loops. PMID: 29657305

Topology of RNA:DNA Hybrids and R-Loops in Yeast. PMID: 35704201

Detection of DNA-RNA Hybrids In Vivo. PMID: 29043635