羅米司亭Nplate(Romiplostim)相關(guān)產(chǎn)品：

Anti-Romiplostim (Nplate) ELISA Kit (KAD76501)

Mouse Anti-Romiplostim Polyclonal Antibody (PHE26003)

Anti-Romiplostim Monoclonal Antibody (1A430) (MHE26001)

Anti-Romiplostim Monoclonal Antibody (1A431) (MHE26002)

Anti-Romiplostim Monoclonal Antibody (1A432) (MHE26003)

Anti-Romiplostim Polyclonal Antibody (PHE26002)

Recombinant Romiplostim Protein, N-Fc (EHE26002)

Anti-Romiplostim (Nplate) ELISA Kit（KAD76501）

背景：Romiplostim是一種血小板生成刺激二聚體Fc肽融合蛋白（肽體），通過(guò)激活血小板生成素受體來(lái)增加血小板生成。肽體分子有兩個(gè)相同的單鏈亞基，每個(gè)亞基由269個(gè)氨基酸殘基組成。每個(gè)亞基由一個(gè)IgG1 Fc載體結構域組成，該結構域共價(jià)連接到多肽序列，該多肽序列包含兩個(gè)與血小板生成素受體c-Mpl相互作用的結合結構域。每個(gè)結構域由14個(gè)氨基酸組成。羅米司亭的氨基酸序列與內源性血小板生成素的氨基酸序列不同。Romiplostim 是通過(guò)大腸桿菌中的重組DNA技術(shù)生產(chǎn)的。

作用機制：Romiplostim是一種血小板生成素受體激動(dòng)劑，可通過(guò)c-Mpl激活細胞內轉錄途徑以增加血小板的產(chǎn)生。它的作用也類(lèi)似于血小板生成素（TPO），TPO是一種調節骨髓中血小板產(chǎn)生的內源性糖蛋白激素。

中文名：羅米司亭

英文名：Romiplostim，romiplostim(Nplate)

別名：羅米思婷，羅米司亭

化學(xué)式: C15H14N2O

CAS: 267639-76-9

應用：SDS-PAGE,WB,ELISA,Immunogen,Bioactivity testing in progress

儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

鏈接：https://www.antibodysystem.com/index/search?wd=Romiplostim

產(chǎn)品購買(mǎi)聯(lián)系方式：027-65279366 /18162686757

QQ：2663991332

參考文獻：

Romiplostim Treatment of Chemotherapy-Induced Thrombocytopenia. PMID: 31545663

A Review of Romiplostim Mechanism of Action and Clinical Applicability. PMID: 34079225

Romiplostim. PMID: 18974747

A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies. PMID: 32499239

Romiplostim in adults with newly diagnosed or persistent immune thrombocytopenia. PMID: 33249935

Efficacy and safety of romiplostim in refractory aplastic anaemia: a Phase II/III, multicentre, open-label study. PMID: 33152120

Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study. PMID: 35179784

Romiplostim: a review of its use in immune thrombocytopenia. PMID: 22316355

Romiplostim in children with newly diagnosed or persistent primary immune thrombocytopenia. PMID: 34308495

Romiplostim for the management of pediatric immune thrombocytopenia: drug development and current practice. PMID: 31239245

Romiplostim: a novel thrombopoiesis-stimulating agent. PMID: 19386944

Efficacy and quality of life of Romiplostim in adults and children with immune thrombocytopenia: A review. PMID: 36550870

Romiplostim use in pregnant women with immune thrombocytopenia. PMID: 36156812

Romiplostim in chronic immune thrombocytopenic purpura. PMID: 19843480

Romiplostim management of immune thrombocytopenic purpura. PMID: 19401474

Romiplostim drug presence in pregnancy and lactation. PMID: 36848631

Development of Romiplostim for Treatment of Primary Immune Thrombocytopenia From a Pharmacokinetic and Pharmacodynamic Perspective. PMID: 27056734

Romiplostim and eltrombopag for immune thrombocytopenia: methods for indirect comparison. PMID: 22980701

Romiplostim: a breakthrough treatment for the management of immune thrombocytopenic purpura. PMID: 19200304

Thrombopoietin receptor agonists: ten years later. PMID: 31073079

Experts' review: the emerging roles of romiplostim in immune thrombocytopenia (ITP). PMID: 34313512

Use of Romiplostim during pregnancy as a rescue therapy in primary immune thrombocytopenia: Literature review and case description. PMID: 31116059

Romiplostim for the treatment of chronic immune or idiopathic thrombocytopenic purpura: a single technology appraisal. PMID: 19804691

Development of romiplostim: a novel engineered peptibody. PMID: 25578414

Romiplostim for SARS-CoV-2 Vaccine Induced Immune Thrombocytopenia. PMID: 34757966

Romiplostim: a second-generation thrombopoietin agonist. PMID: 19436840

Romiplostim for the management of perioperative thrombocytopenia. PMID: 29767837

Immune Thrombocytopenia in a Kidney Transplant Recipient Treated with Romiplostim. PMID: 35033295

Romiplostim-induced myelofibrosis. PMID: 24175353

Clinical overview and practical considerations for optimizing romiplostim therapy in patients with immune thrombocytopenia. PMID: 33781612

Thrombopoietin Receptor Agonists: Eltrombopag and Romiplostim for the Treatment of Chronic Immune Thrombocytopenia Purpura. PMID: 30880797

Romiplostim for PARP inhibitor-induced thrombocytopenia in solid tumor malignancies. PMID: 36050822

Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial. PMID: 37589942

The development of romiplostim for patients with immune thrombocytopenia. PMID: 21434943

A Review on Romiplostim Mechanism of Action and the Expressive Approach in E. coli. PMID: 38282441

Immunomodulation with romiplostim as a second-line strategy in primary immune thrombocytopenia: The iROM study. PMID: 37735543

Romiplostim for temozolomide-induced thrombocytopenia in glioblastoma: The PLATUM trial. PMID: 31586022

Romiplostim in aplastic anaemia - another tool in the armamentarium. PMID: 33152102

Eltrombopag versus romiplostim in treatment of children with persistent or chronic immune thrombocytopenia: a systematic review incorporating an indirect-comparison meta-analysis. PMID: 29330464

Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists. PMID: 34160821

Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim? PMID: 31214173

Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy. PMID: 28408804

Safety of romiplostim and eltrombopag for children with immune thrombocytopenia: a pharmacovigilance study of the FDA adverse event reporting system database. PMID: 36803342

Romiplostim for Primary Immune Thrombocytopenia in Routine Clinical Practice: Results from a Multicentre Observational Study in Germany. PMID: 34959233

An update on romiplostim for treatment of acute radiation syndrome. PMID: 35274632

Romiplostim-related myelofibrosis in refractory primary immune thrombocytopenia: A Case report. PMID: 31232923

Romiplostim (Nplate()) as an effective radiation countermeasure to improve survival and platelet recovery in mice. PMID: 31021662

Comparability of biosimilar romiplostim with originator: Protein characterization, animal pharmacodynamics and pharmacokinetics. PMID: 36871442

Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside. PMID: 20298251

Successful treatment of refractory secondary immune thrombocytopenia (antiphospholipid antibody syndrome-associated) with the combination of rituximab and romiplostim at the cost of severe bone pain: A case report and review of literature. PMID: 32611269

Romiplostim as Adjunctive Treatment of Refractory Amegakaryocytic Immune Thrombocytopenia in a Dog. PMID: 33115689

Romiplostim for thrombocytopenia following allogeneic stem cell transplantation: A case series. PMID: 30030975

Romiplostim use for thrombocytopenia following allogeneic hematopoietic stem cell transplantation: a case series from a single center in Qatar. PMID: 37961987

Assessment of romiplostim immunogenicity in pediatric patients in clinical trials and in a global postmarketing registry. PMID: 34638135

Romiplostim treatment for children with immune thrombocytopenia: Results of an integrated database of five clinical trials. PMID: 32902132

Romiplostim in the management of the thrombocytopenic surgical patient. PMID: 26033367

Romiplostim for Immune Thrombocytopenia in Neuroblastoma Patients Receiving Chemotherapy. PMID: 29683946

Efficacy of romiplostim in treatment of thrombocytopenia in children with Wiskott-Aldrich syndrome. PMID: 33131064

Romiplostim for management of chemotherapy-induced thrombocytopenia. PMID: 24414994

Romiplostim for therapy-related thrombocytopenia in pediatric malignancies. PMID: 28150377

A Novel Use of Romiplostim for SARS-CoV-2-induced Thrombocytopenia. PMID: 33003146

Generic romiplostim for children with persistent or chronic immune thrombocytopenia: Experience from a tertiary care centre in North India. PMID: 35467751